Article

Adaptive deep brain stimulation timed to gait phase improves walking in Parkinson’s disease

2025-08-21

Abstract excerpt

Gait dysfunction in Parkinson’s disease (PD) is a major source of disability and is often resistant to traditional deep brain stimulation (DBS). Here, we report a novel neuromodulation paradigm, gait-phase-synchronized adaptive DBS (aDBS), that dynamically modulates stimulation amplitude during contralateral leg swing. In five individuals with PD, we identified personalized neural biomarkers of gait phase from cor...

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Identifiers and source

Literature Corpus work: d72bb009-44c0-5f6b-bbd5-4e250adb8267
DOI: 10.1101/2025.08.19.25333759

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