Article

Evaluating latent class modelling as the reference standard for interim analysis of multi-rater multi-case diagnostic test accuracy studies

2026-05-12

Abstract excerpt

<title>Abstract</title> 1.1 Background Deciding optimal patient and rater sample sizes for multi-rater multi-case (MRMC) diagnostic test accuracy (DTA) studies is challenging. These studies estimate the individual and average accuracies of raters for an index test, yet sample size decisions often rely on available resources rather than statistical reasoning. Although larger samples reduce bias and increase pr...

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Literature Corpus work: d7123aa8-8f6a-5c0d-a856-faeb0bceecdb
DOI: 10.21203/rs.3.rs-9021498/v1

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