Mitophagosomes induced during EV-D68 infection promote viral nonlytic release

Abstract excerpt

Enterovirus-D68 (EV-D68) is a plus-strand RNA virus that primarily causes infant respiratory infections. In rare pediatric cases, infection with EV-D68 has been associated with acute flaccid myelitis, a polio-like paralytic disease. We have previously demonstrated that EV-D68 induces nonselective autophagy for its benefit. Here, we demonstrate that EV-D68 induces mitophagy, the specific autophagic degradation of m...

Topics

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• Autophagy in Disease and Therapy
• CRISPR and Genetic Engineering
• Cytomegalovirus and herpesvirus research
• Extracellular vesicles in disease
• Immune cells in cancer
• Inflammasome and immune disorders
• Mosquito-borne diseases and control
• RNA regulation and disease

Identifiers and source

Literature Corpus work

d6a2aa0a-fac2-59b3-88f2-48ce155c906b

DOI

10.1101/2024.12.05.627125