Article

Methodological choices strongly modulate the sensitivity and specificity of lesion-symptom mapping analyses

2025-11-06

Abstract excerpt

Lesion mapping results can vary substantially as a function of specific analysis parameters, but the extent to which individual methodological choices interact to modulate the sensitivity and specificity of results is not clear. Here, we employed a large-scale simulation approach to inform practical recommendations for lesion symptom mapping studies. Routine clinical imaging from 959 stroke survivors (mean age = 7...

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Literature Corpus work: d605406e-38f2-54e6-926e-6a7fde986ba4
DOI: 10.1101/2025.11.04.686650

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