Bayesian stroke modeling details sex biases in the white matter substrates of aphasia

Abstract excerpt

Ischemic cerebrovascular events often lead to aphasia. Previous work provided hints that such strokes may affect women and men in distinct ways. Women tend to suffer strokes with more disabling language impairment, even if the lesion size is comparable to men. In 1,401 patients, we isolated data-led representations of anatomical lesion patterns and hand-tailored a Bayesian analytical solution to carefully model th...

Topics

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• Brain
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Neuroimaging
• Phenotype
• Polymorphism, Single Nucleotide
• Stroke

Identifiers and source

Literature Corpus work

bf9371b9-e22b-54fc-baf5-ca6aa1cd8b3f

DOI

10.1101/2022.01.18.474989