Article

A Foundational Exome Resource for Jordan: Dual Ancestry Admixture and Population-Specific Variants to Improve Clinical Variant Interpretation

2026-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Currently, the genetic architecture of Middle Eastern populations is underrepresented in global genomic databases. This gap increases the rate of Variants of Uncertain Significance (VUSs) and clinical misinterpretations of genomic data especially in Middle Eastern populations. Whole exome sequencing was conducted on 90 healthy individuals from Jordan and the data were analysed using Principal Co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5b68603-fa60-599e-9e1d-a9628e0635b5
DOI: 10.64898/2026.05.23.26353895

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Foundational Exome Resource for Jordan: Dual Ancestry Admixture and Population-Specific Variants to Improve Clinical Variant InterpretationDOI 10.64898/2026.05.23.26353895Read

Common disease-associated gene variants in a Saudi Arabian populationSemantic proximity Read

EGP1K: Whole-Genome Sequencing of 1,024 Egyptians Characterizes Population Structure and Genetic DiversitySemantic proximity Read

Understanding local population genetics improves variant interpretation in rare genetic disordersSemantic proximity Read

Pathogenic variation underlying rare diseases in an Arab Population: implications for screening programsSemantic proximity Read

A Copernican revolution of multigenic analysis: A retrospective study on clinical exome sequencing in unclear genetic disordersSemantic proximity Read

AVDB: The Arab Variation and Disease Burden DatabaseSemantic proximity Read

Human Exome Sequencing and Prospects for Predictive Medicine: Analysis of International Data and Own ExperienceSemantic proximity Read

Genetic landscape of rare autoinflammatory disease variants in Qatar and Middle Eastern populations through the integration of whole-genome and exome datasetsSemantic proximity Read

The impact of the Turkish (TK) population variome on the genomic architecture of rare disease traitsSemantic proximity Read

Burden of Mendelian disorders in a large Middle Eastern biobank.Semantic proximity Read

Findings of a 1303 Korean whole-exome sequencing study.Semantic proximity Read

An integrated personal and population-based Egyptian genome reference.Semantic proximity Read