Article

Overcoming Matrix Effects in AAV Neutralization Assays with a Constant Serum Concentration Approach

2025-06-16

Abstract excerpt

<title>Abstract</title> <p>Sensitive quantification of adeno-associated virus (AAV) neutralizing antibodies (NAbs) is essential for gene therapy success. Conventional cell-based transduction inhibition assays often encounter matrix-induced artifacts resulting from variable serum content across dilutions, which artificially inflate transduction baselines and mask partial neutralization. To address this challenge,...

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Literature Corpus work: d5844693-caf4-5dc0-804d-9e0b006a89af
DOI: 10.21203/rs.3.rs-6803148/v1

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