Article

Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data

2020-01-01

Abstract excerpt

Adverse drug effects are unintended and undesirable effects of medicines, causing attrition of molecules in drug development and harm to patients. To anticipate potential adverse effects early, drug candidates are commonly screened for pharmacological activity against a panel of protein targets. However, there is a lack of large-scale, quantitative information on the links between routinely screened proteins and t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d570185b-973d-51b8-8d84-cf9cf84ba194
DOI: 10.17863/cam.65132

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic dataDOI 10.17863/cam.65132Read

Clinical Association Between Pharmacogenomics and Adverse Drug ReactionsSemantic proximity Read

A Real-World Disproportionality Analysis of Two Typical First-Generation TRK Inhibitors: Findings from the FDA Adverse Event Reporting System DatabaseSemantic proximity Read

Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions.Semantic proximity Read

Pharmacovigilance study of BCR-ABL1 tyrosine kinase inhibitors: A safety analysis of the FDA Adverse Event Reporting SystemSemantic proximity Read

Safety assessment of S-1: Real-world adverse event analysis from the FAERS databaseSemantic proximity Read

Delineating Drug Class and Target-Specific Adverse Events of Kinase InhibitorsSemantic proximity Read

Reported Drug Spectrum and Disproportionality Signals for Malignant Neoplasm Progression in FAERS: A Real-World Pharmacovigilance StudySemantic proximity Read

Utility of some International Classification of Diseases 10th revision codes for detecting serious and interesting adverse drug reactions.Semantic proximity Read

Genomics of Adverse Drug Reactions.Semantic proximity Read

Adverse drug reactions associated with the use of biological agentsSemantic proximity Read

Quantifying the severity of adverse drug reactions using social mediaSemantic proximity Read

ProToxNet: Expression-Aware Proteome-Wide Binding for Tissue-Stratified Adverse Event PredictionSemantic proximity Read