Article

COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and may be modified by dexamethasone

2021-01-04

Abstract excerpt

We performed comparative lower respiratory tract transcriptional profiling of 52 critically ill patients with ARDS from COVID-19 or other etiologies, or without ARDS. We found no evidence of cytokine storm but instead observed complex host response dysregulation driven by genes with non-canonical roles in inflammation and immunity that were predicted to be modulated by dexamethasone. Compared to other viral ARDS,...

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Literature Corpus work: d32ce6c9-dc0f-505a-b088-784ef157b859
DOI: 10.1101/2020.12.28.20248552

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