Article

Functional Subtypes of Synaptic Dynamics in Mouse and Human

2023-05-24

Abstract excerpt

Synapses show preferential responses to particular temporal patterns of activity. Across individual synapses, there is a large degree of response heterogeneity that is informally or tacitly separated into classes, and typically only two: facilitating and depressing short-term plasticity. Here we combined a kernel-based model and machine learning techniques to infer the number and the characteristics of functionall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2d2d041-8178-5596-9b7d-38a6b569c91d
DOI: 10.1101/2023.05.23.541971

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional Subtypes of Synaptic Dynamics in Mouse and HumanDOI 10.1101/2023.05.23.541971Read

A combinatorial postsynaptic molecular mechanism converts patterns of nerve impulses into the behavioral repertoireSemantic proximity Read

Data-driven synapse classification reveals a logic of glutamate receptor diversitySemantic proximity Read

Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortexSemantic proximity Read

The human and mouse synaptome architecture of excitatory synapses show conserved featuresSemantic proximity Read

Synaptic combinatorial molecular mechanisms generate repertoires of innate and learned behaviorSemantic proximity Read

A comprehensive knowledge base of synaptic electrophysiology in the rodent hippocampal formationSemantic proximity Read

Experiences are encoded by brainwide reprogramming of synaptome architectureSemantic proximity Read

Brain-wide Organization of Post-Synaptic Sites: Three PrinciplesSemantic proximity Read

Simple models of quantitative firing phenotypes in hippocampal neurons: Comprehensive coverage of intrinsic diversity.Semantic proximity Read

Protein trafficking and synaptic demand configure complex and dynamic synaptome architectures of individual neuronsSemantic proximity Read

A dataset of differentiable biologically-derived single neuron modelsSemantic proximity Read

Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptorsSemantic proximity Read