Article

Cilengitide limits the progression of both syndromic and sporadic thoracic aortic aneurysms by targeting alpha V integrins

2025-03-23

Abstract excerpt

Thoracic aortic aneurysm is a life-threatening condition due to either genetic syndromes ( e.g. , Marfan syndrome) or cardiovascular risk factors ( e.g. , hypertension, aging and smoking), which favour the onset of sporadic thoracic aneurysms. Activation of the transforming growth factor-β pathway and dysregulation of mechanotransduction signals in vascular smooth muscle cells play a key role in the development of...

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Literature Corpus work: d169e64d-bc2d-5cdf-8a69-40215d33d145
DOI: 10.1101/2025.03.21.25324435

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