Article

In vivo gene disruption and homology-directed repair in muscles and muscle stem cells using CRISPR/Cas9

2026-07-01

Abstract excerpt

Programmable endonucleases such as CRISPR/Cas9 provide powerful tools to edit mammalian genomes by engaging cellular mechanisms of DNA double-strand break (DSB) repair. CRISPR-catalysed homology-directed repair (CRISPR-HDR), though generally less efficient than other modes of DNA repair, holds particular promise to enable precise sequence replacement by targeted insertion of a homologous DNA template 1,2 . While...

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Literature Corpus work: d03a6953-7e63-5ae0-93fa-ec11a8a35405
DOI: 10.64898/2026.06.30.735705

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