Article

Hog1/p38 and ZAKα drive Shwachman-Diamond syndrome and provide targets to improve cell growth

2026-02-08

Abstract excerpt

Shwachman-Diamond syndrome (SDS) is a ribosomopathy characterized by neutropenia, pancreatic insufficiency, skeletal defects, and predisposition to leukemia. Most cases result from biallelic SBDS mutations that impairing 80S ribosome and polysome assembly. In yeast lacking SDO1 (the SBDS ortholog), growth slows dramatically and the p38 ortholog Hog1 signaling is elevated by multiple types of stress. SBDS-defici...

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Literature Corpus work: cfe7da3d-d215-596f-9b2c-a572be920e5d
DOI: 10.64898/2026.02.05.703873

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