Article

The concurrent docking of diphenoquinone and cholesterol to the human ATP-binding cassette A1

2024-09-19

Abstract excerpt

<title>Abstract</title> <p><bold>Aim: </bold>Spiroquinone (SQ) and 3,3',5,5'-tetra-tert-butyldiphenoquinone (DQ), metabolites of the probucol, promote ABCA1-mediated HDL neogenesis. To further investigate the detailed mechanism, we analyzed the docking pose of these drugs to ABCA1 using GOLD (Genetic Optimization for Ligand Docking) software, an <italic>in silico</italic> structural analysis application. Then, do...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf82ac9f-d30c-5ae5-adc4-5b31cac9900d
DOI: 10.21203/rs.3.rs-4950053/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

The concurrent docking of diphenoquinone and cholesterol to the human ATP-binding cassette A1DOI 10.21203/rs.3.rs-4950053/v1Read

Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking StudiesSemantic proximity Read

In silico design of potent antioxidant compounds using 2D-QSAR Molecular docking ADMET prediction and Molecular dynamic simulationSemantic proximity Read

Development and Validation Molecular Docking Analysis of Human serum albumin (HSA)Semantic proximity Read

<i>In-Silico</i> Analysis of Secondary Metabolites that Modulates Enzymes of Cholesterol TargetSemantic proximity Read

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease.Semantic proximity Read

Ferroptosis-mediated primary open-angle glaucoma: Insight from gene signature and identification of potential small-molecule drugsSemantic proximity Read

The Human ATP-Binding Cassette (ABC) Transporter SuperfamilySemantic proximity Read

Study on the mechanism of action of probucol in the treatment of coronary artery disease based on network pharmacology and molecular docking technologySemantic proximity Read