Article

Tailored treatment and clinical management for DPYD compound heterozygous: a multidisciplinary teamwork

2024-10-30

Abstract excerpt

<title>Abstract</title> <p>Dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is the rate-limiting enzyme governing fluoropyrimidines (FPs) catabolism. Impaired or abrogated DPD enzyme activity is often caused by genetic polymorphisms in the DPYD gene that are well-validated predictors of FP-associated toxicity. Presently, four DPYD variants are included in FP genetic-based dosing guidelines. Patien...

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Literature Corpus work: c968a21f-5b4d-5725-a8b9-7c4337e86a9e
DOI: 10.21203/rs.3.rs-5310617/v1

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