Article

Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity

2023-06-26

Abstract excerpt

<title>Abstract</title> <p>Variability in genes involved in drug pharmacokinetics or drug response can be responsible for suboptimal treatment efficacy or predispose to adverse drug reactions. In addition to common genetic variations, large-scale sequencing studies have uncovered multiple rare genetic variants predicted to cause functional alterations in genes encoding proteins implicated in drug metabolism, tran...

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Literature Corpus work: 195df699-2bac-555a-a32b-c8111a652956
DOI: 10.21203/rs.3.rs-3068182/v1

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