A tumor suppressive long noncoding RNA, DRAIC, inhibits protein translation and induces autophagy by activating AMPK

Abstract excerpt

LncRNAs are long RNA transcripts that do not code for proteins and that have been shown to play a major role in cellular processes through diverse mechanisms. DRAIC, a lncRNA which is downregulated in castration-resistant advanced prostate cancer, inhibits the NF-kB pathway by inhibiting the IκBα kinase. Decreased DRAIC expression predicted poor patient outcome in gliomas and seven other cancers. We now report tha...

Topics

Open a Topic to create a Post that cites this publication.

• Alternative Splicing
• Autophagy in Disease and Therapy
• Cancer-related molecular mechanisms research
• Cell Line, Tumor
• I-kappa B Kinase
• NF-kappa B
• Peroxisome Proliferator-Activated Receptors
• RNA, Long Noncoding

Identifiers and source

Literature Corpus work

c705c61d-c3d8-57cd-a08e-0fda15fbdd3d

DOI

10.1101/2021.06.04.447165