Article

A drug repurposing screen for whipworms informed by comparative genomics

2023-03-03

Abstract excerpt

Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura . Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be repurposed as novel anti-whipworm drugs. In a previous comparative genomics analysis, we identified 409 drugs approved for human use that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5a67802-7370-5531-ac7d-72e9f44cd7cc
DOI: 10.1101/2023.03.02.530747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A drug repurposing screen for whipworms informed by comparative genomicsDOI 10.1101/2023.03.02.530747Read

High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasitesSemantic proximity Read

Genomic and morphological characterization of <i>Trichuris incognita</i> , a Human-Infecting <i>Trichuris</i> speciesSemantic proximity Read

Identification and Inhibition of GLUT like proteins in <i>Trichuris spp</i> as a druggable targetSemantic proximity Read

Characterisation of <i>Trichuris muris</i> secreted proteins and extracellular vesicles provides new insights into host-parasite communicationSemantic proximity Read

Gut microbial communities modulate efficacy of albendazole-ivermectin against soil-transmitted helminthiasesSemantic proximity Read

Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human and Mouse HostsSemantic proximity Read

Screening the Medicines for Malaria Pandemic Response Box chemical library on <i>Caenorhabditis elegans</i> identifies re-profiled candidate anthelmintic drug leadsSemantic proximity Read

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discoverySemantic proximity Read

Genetic variation in codons 167, 198 and 200 of the beta-tubulin gene in whipworms (Trichuris spp.) from a range of domestic animals and wildlife.Semantic proximity Read

Nanopore-based analysis unravels the genetic landscape and phylogenetic relationships of human-infecting <i>Trichuris incognita</i> and <i>Trichuris trichiura</i> in Côte d’Ivoire, Uganda, Tanzania, and LaosSemantic proximity Read

Whipworm phosphotome identification and analysis: exploring phosphatases as druggable targetsSemantic proximity Read

The genome and developmental transcriptome of the strongylid nematode Haemonchus contortusSemantic proximity Read