Mendelian randomization to inform a clinical trial of chitotriosidase inhibition for pulmonary sarcoidosis

Abstract excerpt

<h4>Background</h4> Current sarcoidosis treatment is limited to glucocorticoids and immunosuppressants that provide symptomatic relief but carry significant side effects. Chitotriosidase 1 (CHIT1) has been correlated with disease severity and is highly expressed in sarcoidosis granulomas, making it an attractive therapeutic target for disease modification. <h4>Research design and methods</h4> We performed Mendel...

Topics

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• Autoimmune Diseases
• Case-Control Studies
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide
• Sarcoidosis
• Sarcoidosis and Beryllium Toxicity Research

Identifiers and source

Literature Corpus work

c4e87590-62a4-5b98-9c5d-5ac14e4f31b3

DOI

10.1101/2025.09.25.25336344