Article

A Systematic Multi-LLM AI Framework for Immunotherapy Biomarker Discovery and Target Identification

2025-06-15

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint inhibitors have revolutionized cancer therapy, yet their efficacy is frequently limited by primary and acquired resistance. This underscores the need for novel immune regulatory targets that can improve or broaden patient responsiveness to immunotherapy. Among these, immunoglobulin (Ig) domain-containing proteins play central roles in immune signaling and tumor immune evasion,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c48f0c0b-843d-525c-be88-3a70ec32be94
DOI: 10.1101/2025.06.10.658988

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Systematic Multi-LLM AI Framework for Immunotherapy Biomarker Discovery and Target IdentificationDOI 10.1101/2025.06.10.658988Read

IMMUNIA: A Multi-LLM Reasoning Agent for Immunoregulatory Surfaceome DiscoverySemantic proximity Read

AI-HOPE: An AI-Driven conversational agent for enhanced clinical and genomic data integration in precision medicine researchSemantic proximity Read

AI-powered integration of multi-source data for TAA discovery to accelerate ADC and TCE drug development (I): TAA Target Identification and PrioritizationSemantic proximity Read

Explainable artificial intelligence for multi-modal cancer analysis: From genomics to immunologySemantic proximity Read

Agentic RAG-Driven Multi-Omics Analysis for PI3K/AKT Pathway Deregulation in Precision MedicineSemantic proximity Read

A Novel Patient-specific Protein Expression-based Algorithmic Model for Immune Checkpoint Inhibition Therapy Response Prediction in a Pan-cancer CohortSemantic proximity Read

Artificial Intelligence in Biomedical Data Analysis: A Comparative Assessment of Large Language Models for Automated Clinical Trial Interpretation and Statistical EvaluationSemantic proximity Read

A Data-Intelligence-Intensive Bioinformatics Copilot System for Large-scale Omics Researches and Scientific InsightsSemantic proximity Read

Evaluating agentic AI for biological discovery in autonomous and copilot settingsSemantic proximity Read

Target and Biomarker Exploration Portal for Drug DiscoverySemantic proximity Read

Generation of guideline-based clinical decision trees in oncology using large language modelsSemantic proximity Read

Integrating Omics Data and AI for Cancer Diagnosis and Prognosis: A Systematic ReviewSemantic proximity Read