Article

CRISPR/Cas9-Based Edition of Frataxin Gene in <i>Dictyostelium discoideum</i> for Friedreich’s Ataxia Disease Modeling

2023-02-28

Abstract excerpt

In this paper we describe the development of a new model system for Friedreich’s Atax- ia (FA) using Dictyostelium discoideum . We investigated the conservation of function between humans and D. discoideum and showed that DdFXN can substitute the human version in the interaction and activation of the Fe-S assembly supercomplex. We edited the fxn locus and isolated a defective mutant, clone 8, which presents lan...

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Literature Corpus work: c3977bc3-962c-5396-9ac1-d357757cccaf
DOI: 10.1101/2023.02.27.530330

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