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Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells

2023-10-06

Abstract excerpt

<title>Abstract</title> <p>Almost all non-small cell lung cancer (NSCLC) patients initially responding to EGFR tyrosine kinase inhibitors (TKIs) develop acquired resistance. Since K<sub>Ca</sub>3.1 channels, expressed in mitochondria and plasma membrane, regulate similar behavioral traits of NSCLC cells as EGFR, we hypothesized that their blockade contributes to overcoming EGFR-TKI resistance. Meta-analysis of mi...

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Literature Corpus work
c263c617-c20a-5b04-b973-f41dadd0873b
DOI
10.21203/rs.3.rs-3389641/v1
Open publication

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Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cellsDOI 10.21203/rs.3.rs-3389641/v1
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