Article

Disease-Linked Super-Trafficking of a Mutant Potassium Channel

2020-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Gain-of-function (GOF) mutations in the KCNQ1 voltage-gated potassium channel can induce cardiac arrhythmia. We tested whether any of the known GOF disease mutations in KCNQ1 act by increasing the amount of KCNQ1 that reaches the cell surface—“super-trafficking”. We found that levels of R231C KCNQ1 in the plasma membrane are 5-fold higher than wild type KCNQ1. This arises from both enhanced tran...

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Literature Corpus work: c2323c4c-8050-5daf-bd84-1c2f62794835
DOI: 10.1101/2020.07.29.227231

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