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Article

Disease-linked supertrafficking of a potassium channel.

The Journal of biological chemistry - 1 Jan 2000

Huang Hui, Chamness Laura M, Vanoye Carlos G, Kuenze Georg, Meiler Jens, George Alfred L, Schlebach Jonathan Patrick, Sanders Charles R

Abstract excerpt

Gain-of-function (GOF) mutations in the voltage-gated potassium channel subfamily Q member 1 (KCNQ1) can induce cardiac arrhythmia. In this study, it was tested whether any of the known human GOF disease mutations in KCNQ1 act by increasing the amount of KCNQ1 that reaches the cell surface-"supertrafficking." Seven of the 15 GOF mutants tested were seen to surface traffic more efficiently than the WT channel....

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Identifiers

PMID: 33600800
DOI: 10.1016/j.jbc.2021.100423
PMCID: PMC7988323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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