CAR-T cells Targeting Thyroid-stimulating Hormone Receptor (TSHR) Demonstrate Safety and Potent Preclinical Activity Against Differentiated Thyroid Cancer

Abstract excerpt

<h4>Background</h4> Differentiated thyroid cancer (DTC) is usually very treatable and is often cured with surgery and, if indicated, follow with radioactive iodine (RAI) and long-term thyroid-stimulating hormone (TSH) suppression with levothyroxine. Unfortunately, locoregional relapse and distant metastases occur in up to 20% at ten years; those relapsed or distant metastatic thyroid cancer is relatively uncommon...

Topics

Open a Topic to create a Post that cites this publication.

• Immunotherapy
• Molecular Diagnostic Techniques
• Molecular Targeted Therapy
• Mutation
• Paired Box Transcription Factors
• PAX8 Transcription Factor
• Proto-Oncogene Proteins c-ret
• Thyroid Neoplasms

Identifiers and source

Literature Corpus work

289c228f-275f-5f1e-be5e-407fd99011f9

DOI

10.1101/2021.05.15.21256466