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Immature dendritic cell-targeting mRNA vaccine expressing PfCSP enhances protective immune responses against Plasmodium liver infection

2024-07-09

Abstract excerpt

<title>Abstract</title> <p>Resurgence in malaria has been noted in 2022 with 249 million clinical cases resulting in 608,000 deaths, mostly in children under five. Two vaccines, RTS, S, and more recently R21, targeting the circumsporozoite protein (CSP) are recommended by the WHO but are not yet widely available. Strong humoral responses to neutralize sporozoites before they can infect the hepatocytes are importa...

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Literature Corpus work
c0d53f97-2d19-5286-b159-5f77a98f4c48
DOI
10.21203/rs.3.rs-4656309/v1
Open publication

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Immature dendritic cell-targeting mRNA vaccine expressing PfCSP enhances protective immune responses against Plasmodium liver infectionDOI 10.21203/rs.3.rs-4656309/v1
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