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Muddying the Waters: Syncytial Variant Nodular Sclerosis Classic Hodgkin Lymphomas Exhibit a Primary Mediastinal Large B-cell Lymphoma-Like Gene Expression Profile Using the Lymph3Cx Gene Expression Profiling Assay

2025-05-13

Abstract excerpt

Mediastinal B-cell lymphomas are relatively frequent in young patients and include nodular sclerosis classic Hodgkin lymphoma (NSCHL), primary mediastinal large B-cell lymphoma (PMBL), and rarely, mediastinal gray zone lymphoma (MGZL). Occasional NSCHLs contain abundant Hodgkin/Reed Sternberg (HRS) cells that exhibit a syncytial growth pattern, which may create diagnostic challenges. Previous studies have demonstr...

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Literature Corpus work: c04b6c4a-d22b-5091-9653-df3a2b486ac9
DOI: 10.1101/2025.05.12.25327251

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