Article

Multi-Omic Integration of the miRNome and Transcriptome in Dermal Fibroblasts from Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Reveals Convergent Regulation of Extracellular Matrix Remodeling and Inflammatory Pathways

2026-08-28

Abstract excerpt

Hypermobile Ehlers–Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are clinically diagnosed connective tissue conditions without validated molecular biomarkers. We investigated whether miRNA-mediated post-transcriptional regulation converges between them. miRNome sequencing was performed in dermal fibroblasts from 12 hEDS, 12 HSD, and 24 control individuals, followed by qPCR assessment of 25 sele...

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Literature Corpus work: c01680bf-166c-5aae-a72c-e0934d203959
DOI: 10.20944/preprints202608.2130.v1

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Multi-Omic Integration of the miRNome and Transcriptome in Dermal Fibroblasts from Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Reveals Convergent Regulation of Extracellular Matrix Remodeling and Inflammatory PathwaysDOI 10.20944/preprints202608.2130.v1Read

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