Article

Genetic background shapes AI-predicted variant effects

2026-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Predicting the consequences of genetic variants remains a major goal in biomedicine. Conventional approaches typically assess single-nucleotide variants in the context of a single reference genome, without accounting for genetic diversity that can modulate variant effects. Here we introduce the personalized variant effect predictor (pVEP) framework, which quantifies how genetic background across...

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Literature Corpus work: bf65d65e-90aa-51d9-a154-4ece94546046
DOI: 10.64898/2026.04.04.715328

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