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Exploring Potential Minocycline–ARH3 Interactions in <i>ADPRHL2</i> -Associated CONDSIAS: A Translational Clinical and Computational Study

2026-07-10

Abstract excerpt

<h4>Background</h4> Stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (CONDSIAS) is a rare autosomal recessive disorder caused by biallelic variants in ADPRHL2 , which encodes ADP-ribosylhydrolase 3 (ARH3), a key enzyme involved in poly (ADP-ribose) (PAR) metabolism. Although Minocycline has been reported to attenuate PAR-mediated neurotoxicity primarily through modulation of PAR...

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Literature Corpus work
be131b99-f75b-5016-9483-a05eeb299e50
DOI
10.64898/2026.07.09.26357651
Open publication

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