Article

The effect of hydroxyurea response on gut microbiota of beta-thalassemia major patients

2023-04-12

Abstract excerpt

<h4>Background: </h4> Hydroxyurea (HU), a fetal hemoglobin inducer is effective in alleviating the symptoms of beta-thalassemia patients; however, its efficacy is not the same in all patients. Hydroxyurea metabolism in the gut might be responsible, which, as several studies suggest, impacts the metabolism of drugs and diseases including sickle cell diseasea and thalassemia. Hydroxyurea also influences the composit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba037eb0-9d61-5855-9cfe-135c1fc2d489
DOI: 10.21203/rs.3.rs-2797245/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The effect of hydroxyurea response on gut microbiota of beta-thalassemia major patientsDOI 10.21203/rs.3.rs-2797245/v1Read

How Hydroxyurea Alters the Gut Microbiome: A Longitudinal Study Involving Angolan Children with Sickle Cell AnemiaSemantic proximity Read

Differential gut microbiota composition in β-Thalassemia patients and its correlation with iron overloadSemantic proximity Read

Hydroxyurea Treated β-Thalassemia Children Demonstrate a Shift in Metabolism Towards Healthy PatternSemantic proximity Read

Iron deficiency anemia-related gut microbiota dysbiosis in infants and young children: A pilot studySemantic proximity Read

Gut microbiota remodeling in HBB-mutant cynomolgus monkeys reveals blood-gut axis disruption associated with β-thalassemia-related gastrointestinal dysfunction.Semantic proximity Read

Altered Gut Microbiota as a Potential Risk Factor for two types of anemia: insights from Mendelian randomization analysisSemantic proximity Read

Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?Semantic proximity Read

A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemicSemantic proximity Read

Gene polymorphisms predicting response to hydroxyurea treatment in Bahraini patients with sickle cell disease.Semantic proximity Read

Lactobacillus gasseri LG08 and Leuconostoc mesenteroides LM58 exert preventive effect on the development of hyperuricemia by repairing antioxidant system and intestinal flora balanceSemantic proximity Read

Pharmacoproteomics Profiling of Plasma From β‐Thalassemia Patients in Response to Hydroxyurea TreatmentSemantic proximity Read

The gut microbiome in sickle cell disease: Characterization and potential implicationsSemantic proximity Read