Article

Dual transgenesis of T cells with a CD44v6-specific chimeric antigen receptor and a suicide gene for the safe eradication of chemoresistant leukaemia and myeloma

2012-01-01

Abstract excerpt

The recent and extraordinaire clinical successes of T cells modified with chimeric antigen receptors (CAR) against B-cell tumours indicate this strategy as the new frontier for the immunotherapy of haematological malignancies. In this study, we investigated a new CAR-based strategy for the treatment of acute myeloid leukaemia (AML) and multiple myeloma (MM). The ultimate goal of cancer treatment is the elimination...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b97c980e-5882-52a3-a724-c1970eb9cdd5
DOI: 10.21954/ou.ro.0000ffd2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual transgenesis of T cells with a CD44v6-specific chimeric antigen receptor and a suicide gene for the safe eradication of chemoresistant leukaemia and myelomaDOI 10.21954/ou.ro.0000ffd2Read

CD44v6 chimeric antigen receptor T cell specificity towards AML with FLT3 or DNMT3A mutations.Semantic proximity Read

Dual chimeric antigen receptor T cells targeting CD38 and SLAMF7 with independent signalling demonstrate efficacy and safety in preclinical models of Multiple MyelomaSemantic proximity Read

Adoptive Cellular Therapy for Multiple Myeloma Using CAR- and TCR-Transgenic T Cells: Response and ResistanceSemantic proximity Read

T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignanciesSemantic proximity Read

Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myelomaSemantic proximity Read

Generation of a stable anti-human CD44v6 scFv and analysis of its cancer-targeting ability in vitroSemantic proximity Read

Targeting CD45 by gene-edited CAR-T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioningSemantic proximity Read

Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide GeneSemantic proximity Read

Targeting CD45 by gene-edited CAR T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioningSemantic proximity Read

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo.Semantic proximity Read

Untouched GMP-Ready Purified Engineered Immune Cells to Treat CancerSemantic proximity Read

Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7Semantic proximity Read