Back to search

Article

α -Lipoic Acid-Plus Ameliorates Endothelial Injury via Inhibiting the Apoptosis Pathway Mediated by Intralysosomal Cathepsins in Vivo and Vitro Endothelial Injury Model

2021-02-10

Abstract excerpt

<h4>Purpose: </h4> We tried to explore the potential role of the α-Lipoic acid-plus (LAP) in endothelial injury in vitro and vivo models. Simultaneously, possible endovascular protective mechanisms of LAP were also investigated further. Methods In vitro , oxyhemoglobin (OxyHb) stimulating human umbilical vein endothelial cells (HUVECs) simulated intimal injury. In vivo , carotid artery angioplasty injury was used...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b925c4f4-7a5f-59d0-8016-4fa30fa39af7
DOI
10.21203/rs.3.rs-180944/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
α -Lipoic Acid-Plus Ameliorates Endothelial Injury via Inhibiting the Apoptosis Pathway Mediated by Intralysosomal Cathepsins in Vivo and Vitro Endothelial Injury ModelDOI 10.21203/rs.3.rs-180944/v1
Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulabilitySemantic proximity
Potential Mechanism of HXSJ Decoction in the Treatment of Venous Leg Ulcer: Based on the Association between Venous Leg Ulcers and FerroptosisSemantic proximity
Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine.Semantic proximity
N-acetylcysteine resists high-glucose-induced injury of human umbilical vein endothelial cells by inhibiting the leptin/leptin receptorSemantic proximity
In vitro and in vivo molecular analysis of cyclooxygenase-2 (COX-2)-dependent and COX-2 independent cytoprotective pathways in the vascular endotheliumSemantic proximity
Vascular endothelial cell injury: causes, molecular mechanisms, and treatmentsSemantic proximity
Oxidative Stress in Placenta: Health and DiseasesSemantic proximity
The role of ferroptosis in endothelial cell dysfunctionSemantic proximity
Select a neighboring publication to make it the new centre.