Article

A chromosome level reference genome of Diviners sage (Salvia divinorum) provides insight into salvinorin A biosynthesis

2024-09-13

Abstract excerpt

<h4>Background: </h4> Diviners sage (Salvia divinorum; Lamiaceae) is the source of the powerful hallucinogen salvinorin A (SalA). This neoclerodane diterpenoid is an agonist of the human kappa opioid receptor with potential medical applications in the treatment of chronic pain, addiction, and post-traumatic stress disorder. Only two steps of the approximately twelve step biosynthetic sequence leading to SalA have...

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Literature Corpus work: b700ff12-37e8-5fcd-9cbf-b51b9247bc79
DOI: 10.1101/2024.09.08.611878

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