Article

Exosomes and exosomal miRNAs from muscle-derived fibroblasts promote skeletal muscle fibrosis

2018-02-19

Abstract excerpt

We investigated in vitro and in vivo the pro-fibrotic role of exosomes released by muscle-derived fibroblasts of Duchenne muscular dystrophy (DMD) patients, and of miRNAs carried by exosomes. We found that exosomes from DMD fibroblasts, but not from myoblasts, had significantly higher levels of miR-199a-5p, a miRNA up-regulated in fibrotic conditions, compared to control exosomes. In control fibroblasts, exposure...

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Literature Corpus work: b6b98688-f69c-5056-b776-e1b5f270c0f4
DOI: 10.1101/267963

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