Article

Topic modelling with ICD10-informed priors identifies novel genetic loci associated with multimorbidities in UK Biobank

2022-10-30

Abstract excerpt

<h4>Summary</h4> Studies of disease incidence have identified thousands of genetic loci associated with complex traits. However, many diseases occur in combinations that can point to systemic dysregulation of underlying processes that affect multiple traits. We have developed a data-driven method for identifying such multimorbidities from routine healthcare data that combines topic modelling through Bayesian binar...

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Literature Corpus work: b635a716-0fb0-5d4b-afcc-84856eefd741
DOI: 10.1101/2022.10.28.22281623

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