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Clinical efficacy and neurobiological correlates of electroconvulsive therapy in patients with clozapine-resistant/intolerant schizophrenia: study protocol of multi-site parallel arm double-blind randomized sham-controlled study

2022-10-05

Abstract excerpt

<h4>Background: </h4> A substantial proportion of patients with treatment resistant schizophrenia do not respond well or partially to clozapine, with a subset that does not tolerate an adequate trial of clozapine. Electroconvulsive therapy (ECT) is regarded as one of the augmenting options, but there is a lack of high-quality evidence for this practice. This protocol describes a double-blind randomised sham-contro...

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Literature Corpus work
b4cd26f4-db97-5a38-b620-b826650fc01f
DOI
10.12688/wellcomeopenres.18028.2
Open publication

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Clinical efficacy and neurobiological correlates of electroconvulsive therapy in patients with clozapine-resistant/intolerant schizophrenia: study protocol of multi-site parallel arm double-blind randomized sham-controlled studyDOI 10.12688/wellcomeopenres.18028.2
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