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Functional Role of NOXA in Hypoxia-Mediated PD-L1 Inhibitor Response in Hepatocellular Carcinoma

2025-03-24

Abstract excerpt

Hypoxia is a crucial characteristic of hepatocellular carcinoma (HCC) and contributes to immune resistance by upregulating PD-L1 and recruiting immunosuppressive cells. However, the molecular mechanisms of hypoxia-induced immunotherapy resistance are still unclear. The hypoxia-related immunotherapy response (IRH) genes were identified and developed a hypoxia risk score model to predict patient survival. The model...

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Literature Corpus work
b1b24d18-9d48-5a34-b5ff-2c97e217e68e
DOI
10.20944/preprints202503.1680.v1
Open publication

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