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Anti-CMV IgG Titre Determines Organ-Specific Protection Towards Immune Checkpoint Blockade Induced Toxicities

2025-11-09

Abstract excerpt

Seropositivity for human cytomegalovirus (CMV) is associated with protection against severe (Grade 3+) immune-related adverse events (irAEs) post Immune Checkpoint Blockade (ICB). Here, in a prospectively recruited pan-cancer ICB-treated cohort (n=448 patients), we identify a novel relationship between the relative baseline titre of anti-CMV IgG antibody and organ-specific protection against irAEs. In CMV seroposi...

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Literature Corpus work
b0f7a6cc-ef51-5c01-a3bb-d004376c1827
DOI
10.1101/2025.11.07.25339789
Open publication

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Anti-CMV IgG Titre Determines Organ-Specific Protection Towards Immune Checkpoint Blockade Induced ToxicitiesDOI 10.1101/2025.11.07.25339789
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