Pathogen genomic surveillance as a scalable framework for precision phage therapy

Abstract excerpt

Phage therapy is gaining increasing interest in the fight against critically resistant nosocomial pathogens. However, the narrow host range of bacteriophages hampers the development of broadly effective phage therapeutics and demands precision approaches. Here we combine large-scale phylogeographical analysis with high-throughput phage typing to guide the development of precision phage cocktails targeting carbapen...

Topics

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• Acinetobacter baumannii
• Acinetobacter Infections
• Anti-Bacterial Agents
• Bacteriophages
• Bacteriophages and microbial interactions
• Carbapenems
• Disease Models, Animal
• Microbial Sensitivity Tests

Identifiers and source

Literature Corpus work

b05725a0-6cec-5fd4-991e-04a21367190e

DOI

10.1101/2024.06.15.599013