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Article

Impaired protein degradation in FTLD and related disorders.

Ageing research reviews - 1 Dec 2016

Götzl Julia K, Lang Christina M, Haass Christian, Capell Anja

Abstract excerpt

Impaired protein degradation has been discussed as a cause or consequence of various neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's disease. More recently, evidence accumulated that dysfunctional protein degradation may play a role in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Since in almost all neurodegenerative diseases, protein aggregates are...

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Identifiers

PMID: 27166223
DOI: 10.1016/j.arr.2016.04.008

Genes

SQSTM1
GRN

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