Article

DIFFERENTIAL REGULATION OF GENES IN ENTORHINAL CORTEX AND HIPPOCAMPUS IN LATE ONSET AD

2024-09-19

Abstract excerpt

Amyloidogenic processing of APP mediated by increased BACE1 activity resulting in Aβ production and accumulation of hyperphosphorylated tau cause neuronal degeneration in AD. Pathological changes occur early in the EC and the hippocampus, much before neurodegeneration sets in. Here, using 500 and 303 differentially expressed genes from the EC and hippocampus respectively, we observed impairment of several cellular...

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Literature Corpus work: adeb0d5b-4b7e-5c12-9b48-0093929e352b
DOI: 10.1101/2024.09.14.613003

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