Article

Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

2021-04-20

Abstract excerpt

Evolutionary changes in the anatomy and physiology of the female reproductive system underlie the origins and diversification of pregnancy in Eutherian (“Placental”) mammals. This developmental and evolutionary history constrains normal physiological functions and biases the ways in which dysfunction contributes to reproductive trait diseases and adverse pregnancy outcomes. Here, we show that gene expression chang...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: adc535da-4ee5-53ad-b64e-2d9c3100c0c4
DOI: 10.1101/2021.04.19.440514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomesDOI 10.1101/2021.04.19.440514Read

Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomesSemantic proximity Read

The transformative potential of an integrative approach to pregnancy.Semantic proximity Read

Integrative transcriptome meta-analysis reveals widespread sex-biased gene expression at the human fetal-maternal interfaceSemantic proximity Read

Evolutionary transcriptomics implicates <i>HAND2</i> in the origins of implantation and regulation of gestation lengthSemantic proximity Read

Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation lengthSemantic proximity Read

GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes.Semantic proximity Read

Evolution of the genetic architecture of uterine disordersSemantic proximity Read

Temporal placental genome wide expression profiles reflect three phases of utero-placental blood flow during early to mid human gestationSemantic proximity Read

An integrated multimodal pan-organ atlas of the female reproductive system across the lifespan contextualises gynaecological pathologiesSemantic proximity Read

Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal womenSemantic proximity Read

An atlas of transcriptional dynamics in maternal blood over the course of healthy pregnancySemantic proximity Read

Preeclampsia, Natural History, Genes, and miRNAs Associated with the SyndromeSemantic proximity Read