Article
Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination.
Nature medicine - 1 Dec 2019
Bhattacharyya Roby P, Bandyopadhyay Nirmalya, Ma Peijun, Son Sophie S, Liu Jamin, He Lorrie L, Wu Lidan, Khafizov Rustem, Boykin Rich, Cerqueira Gustavo C, Pironti Alejandro, Rudy Robert F, Patel Milesh M, Yang Rui, Skerry Jennifer, Nazarian Elizabeth, Musser Kimberly A, Taylor Jill, Pierce Virginia M, Earl Ashlee M, Cosimi Lisa A, Shoresh Noam, Beechem Joseph, Livny Jonathan, Hung Deborah T
Abstract excerpt
Multidrug resistant organisms are a serious threat to human health1,2. Fast, accurate antibiotic susceptibility testing (AST) is a critical need in addressing escalating antibiotic resistance, since delays in identifying multidrug resistant organisms increase mortality3,4 and use of broad-spectrum antibiotics, further selecting for resistant organisms. Yet current growth-based AST assays, such as broth...
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