Why Microbiome-Mediated Clinical Trials Often Fail to Support Health Claims: A Commentary on Probiotic and Microbiome-Modulating Interventions

Abstract excerpt

The rapid expansion of probiotics and other microbiome-modulating interventions has been accompanied by a growing number of human clinical trials. Yet, despite frequent reports of statistically significant microbiome changes, relatively few studies generate evidence that convincingly supports health claims or translates into reproducible, clinically meaningful outcomes. This gap is often attributed to the inherent...

Topics

Open a Topic to create a Post that cites this publication.

• Biomedical Research
• Clostridium difficile and Clostridium perfringens research
• Diet and metabolism studies
• Gut microbiota and health
• Metagenome
• Microbiota
• Models, Animal
• Probiotics and Fermented Foods

Identifiers and source

Literature Corpus work

ab6d22e5-020c-5ade-804b-0e852438169d

DOI

10.20944/preprints202601.0224.v1