Article

ARID1A Regulates E-Cadherin Expression in Colorectal Cancer Cells: A Promising Candidate Therapeutic Target

2021-06-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Metastasis is a major cause of death in colorectal cancer (CRC) patients, and the epithelial–mesenchymal transition (EMT) has been known to be a crucial event in cancer metastasis. Downregulated expression of AT-rich interaction domain-containing protein 1A (ARID1A), a bona fide tumor suppressor gene, plays an important role in promoting EMT and CRC metastasis, b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aafe799a-85ab-51b4-a03d-f03d266b2699
DOI: 10.21203/rs.3.rs-553289/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ARID1A Regulates E-Cadherin Expression in Colorectal Cancer Cells: A Promising Candidate Therapeutic TargetDOI 10.21203/rs.3.rs-553289/v1Read

Roles of ARID1A variations in colorectal cancer: a collaborative reviewSemantic proximity Read

Loss of ARID1A expression promotes lung adenocarcinoma metastasis and predicts a poor prognosis.Semantic proximity Read

ARID3A promotes the development of colorectal cancer by upregulating AURKASemantic proximity Read

Altered ARID1A expression in colorectal cancerSemantic proximity Read

Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancerSemantic proximity Read

Decreased expression of ARID1A associates with poor prognosis and promotes metastases of hepatocellular carcinomaSemantic proximity Read

ARID1A knockdown enhances carcinogenesis features and aggressiveness of Caco-2 colon cancer cells: An in vitro cellular mechanism studySemantic proximity Read

Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer.Semantic proximity Read

ARID1A in cancer: Friend or foe?Semantic proximity Read

Recent advances in the ARID family: focusing on roles in human cancerSemantic proximity Read

ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer.Semantic proximity Read

Correlation between the expression of metastatic tumor antigen 1 splice variants and aggressive features of colorectal cancerSemantic proximity Read