Article

Multicountry validation of a proteomic host-response signature associated with tuberculosis disease severity

2025-04-03

Abstract excerpt

<h4>Introduction</h4> Non-sputum-based host-response biomarkers are needed to improve detection of tuberculosis (TB) across heterogeneous clinical presentations, particularly in individuals with negative sputum results. We previously identified a 12-marker plasma protein signature associated with TB disease severity. Here, we evaluated the reproducibility and generalizability of this signature across independent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa812602-b195-584b-a038-416335172d9b
DOI: 10.1101/2025.04.02.25324687

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multicountry validation of a proteomic host-response signature associated with tuberculosis disease severityDOI 10.1101/2025.04.02.25324687Read

Proteomic and transcriptomic host biomarkers for detection of pleural tuberculosisSemantic proximity Read

From simple to complex: Protein‐based biomarker discovery in tuberculosisSemantic proximity Read

Plasma host protein signatures correlating with Mycobacterium tuberculosis activity prior to and during antituberculosis treatmentSemantic proximity Read

A protein signature associated with active tuberculosis identified by plasma profiling and network-based analysisSemantic proximity Read

A protein signature associated with active tuberculosis identified by plasma profiling and network-based analysisSemantic proximity Read

Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkersSemantic proximity Read

Gene signature discovery and systematic validation across diverse clinical cohorts for TB prognosis and response to treatmentSemantic proximity Read

Common gene signature model discovery and systematic validation for TB prognosis and response to treatmentSemantic proximity Read

Monocyte transcriptome signatures of inflammation and enhanced neutrophil recruitment characterize immunopathology in the blood of tuberculosis patientsSemantic proximity Read

Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and QuantificationSemantic proximity Read

Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signaturesSemantic proximity Read

Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomesSemantic proximity Read