Article

Uromodulin p.His36Tyr promotes macrophage pyroptosis via App-Cd74 signaling to drive renal inflammation in ADTKD

2025-07-22

Abstract excerpt

<title>Abstract</title> <p>Autosomal dominant tubulointerstitial kidney disease -UMOD (ADTKD-UMOD) is characterized by progressive renal interstitial inflammation and fibrosis. However, its underlying mechanisms remain unclear. Here, we identify a large ADTKD pedigree harboring a novel UMOD p.H36Y mutation. Using CRISPR/Cas9 technology, we generated a UmodH36Y/+ mouse model that recapitulates the key phenotypes o...

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Literature Corpus work: a794546d-9213-5bc9-b877-c63a08211196
DOI: 10.21203/rs.3.rs-7108955/v1

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