Article

Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors

2021-11-09

Abstract excerpt

To date there are no therapies for patients with congenital myopathies, muscle disorders causing poor quality of life of affected individuals. In approximately 30% of the cases, patients with congenital myopathies carry either dominant or recessive mutations in the RYR1 gene; recessive RYR1 mutations are accompanied by reduction of RyR1 expression and content in skeletal muscles and are associated with fiber hyp...

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Literature Corpus work: a62b52ab-348a-5744-908b-03d05df5bdd9
DOI: 10.1101/2021.11.09.467894

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