Article

COVID-19 vaccines dampen genomic diversity of SARS-CoV-2: Unvaccinated patients exhibit more antigenic mutational variance

2021-07-05

Abstract excerpt

Variants of SARS-CoV-2 are evolving under a combination of immune selective pressure in infected hosts and natural genetic drift, raising a global alarm regarding the durability of COVID-19 vaccines. Here, we conducted longitudinal analysis over 1.8 million SARS-CoV-2 genomes from 183 countries or territories to capture vaccination-associated viral evolutionary patterns. To augment this macroscale analysis, we per...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a612016a-e47b-54a7-b7c2-167869f594bf
DOI: 10.1101/2021.07.01.21259833

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

COVID-19 vaccines dampen genomic diversity of SARS-CoV-2: Unvaccinated patients exhibit more antigenic mutational varianceDOI 10.1101/2021.07.01.21259833Read

Emerging Vaccine-Breakthrough SARS-CoV-2 VariantsSemantic proximity Read

Comprehensive genomic, immunological and clinical analysis of COVID-19 vaccine breakthrough infections: a prospective, comparative cohort studySemantic proximity Read

COVID-19 Challenge: A Quest for Effective Vaccine Strategies Against Circulating and Emerging SARS-CoV-2 Variants.Semantic proximity Read

A Comprehensive Account of SARS-CoV-2 Genome structure, Incurred mutations, Lineages and COVID-19 Vaccination ProgramSemantic proximity Read

Dominance of Alpha and Iota variants in SARS-CoV-2 vaccine breakthrough infections in New York City.Semantic proximity Read

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 VariantsSemantic proximity Read

Rapidly Evolving SARS-CoV-2: A Brief Review Regarding the Variants and their Effects on Vaccine Efficacies.Semantic proximity Read

Emerging Omicron Subvariants EG.5 and BA.2.86: Implications for COVID-19 Immunity and SurveillanceSemantic proximity Read

COVID-19, the first pandemic in the post-genomic era.Semantic proximity Read

Emerging Omicron Subvariants EG.5 and BA.2.86: Implications for COVID-19 Immunity and SurveillanceSemantic proximity Read

Bivalent and Monovalent SARS-CoV-2 Variant Vaccine Boosters Improve coverage of the known Antigenic Landscape: Results of the COVID-19 Variant Immunologic Landscape (COVAIL) TrialSemantic proximity Read

Longitudinal effects of SARS-CoV-2 breakthrough infection on imprinting of neutralizing antibody responsesSemantic proximity Read